Computational Biology & Biological Physics (CBBP)
Department of Astronomy and Theoretical Physics
SE-223 62 Lund
Phone: +46 46 2220667
Email: bettina [dot] greese [at] thep [dot] lu [dot] se
My research is in the field of systems biology, more specifically pattern formation in plant development. I use mathematical and computational methods to analyze biological systems based on experimental data. My goal is to further understand the mechanisms that lead to the patterns that are observed in various plant structures, such as leaves and roots. The available data are used to construct mathematical models. The predictions of the following simulations are tested against real data and possibly the model improved. By cooperating with biologists, the mathematical modeling is tightly linked to up-to-date research in experimental biology.
My research at CBBP focuses on the plant root, and it involves mathematical models for different aspects of auxin transport and the development of root hairs. I am part of the group of Prof. Dr. Henrik Jönsson [link]. This work is in collaboration with Prof. Dr. Markus Grebe at Umeå University [link] and embedded in the ShapeSystems project that is funded by the Knut and Alice Wallenberg Foundation.
Previously, I have worked as a scientific assistant and PhD student in the group of Prof. Dr. Jens Timmer at the Center for Biological Systems Analysis (ZBSA) of the University of Freiburg in Germany [link]. My research was supervised by Dr. Christian Fleck [link], it has been on the formation of trichomes (plant hairs) on leaves of the model plant Arabidopsis thaliana. This work was in collaboration with the group of Prof. Dr. Martin Hülskamp at the Universität zu Köln in Germany [link]. For the image analysis we also collaborated with the group of Junior-Prof. Dr.-Ing. Olaf Ronneberger at the Universität Freiburg [link].
Academic Education & Employment
I have studied Biomathematics at the Universität Greifswald in Germany with longer study visits in New Zealand (2003) and Canada (2004 and 2005). In 2006, I obtained my Diplom degree and started working as a scientific assitant and PhD student at the Universität Freiburg in Germany, mainly in the Center for Biosystems Analysis (ZBSA). I obtained my PhD in 2012 and moved to Sweden as a postdoc at Lunds Universitet.
Variability in trichome pattern formation
Greese, B., Hülskamp, M., Fleck, C.
Fontiers in Plant Science (2014) - Invited Review
Birth-jump processes and applications to forest fire spotting
Hillen, T., Greese, B., Martin, J., de Vries, G.
Journal of Biological Dynamics (2014) [link]
Influence of cell-to-cell variability on spatial pattern formation
Greese, B., Wester, K., Bensch, R., Ronneberger, O., Timmer, J., Hülskamp, M., Fleck, C.
IET Systems Biology 6 (4), 143-153 (2012) - Special Issue on Modelling Noise in Biochemical Reaction Networks
Note: Available on the website of Jens Timmer (no. 241) [link]
Image analysis of Arabidopsis trichome patterning in 4D confocal datasets
Bensch, R., Ronneberger, O., Greese, B., Fleck, C., Wester, K., Hülskamp, M., Burkhardt, H.
Proceedings of the 6th IEEE International Symposium on Biomedical Imaging, 742-745 (2009)
A competitive complex formation mechanism underlies trichome patterning on Arabidopsis leaves
Digiuni*, S., Schellmann*, S., Geier*, F., Greese*, B., Pesch, M., Wester, K., Dartan, B., Mach, V., Srinivas, B. P., Timmer, J., Fleck, C., and Hülskamp, M.
Molecular Systems Biology 4, 217 (2008) *These authors contributed equally.
Note: Available on the website of Jens Timmer (no. 169) [link]
Pattern Formation in Plant Developmental Biology: a Study of the Mechanisms Underlying Trichome Initiation using Mathematical Modelling
Doctoral thesis at the University of Freiburg, Germany (Dec 2011)
Development, Analysis and Application of a Nonlinear Integro-Differential Equation in the Context of Cancer Growth
Diplom thesis at the University of Greifswald, Germany (Dec 2005)
Computational modelling of planar cell polarity in the Arabidopsis root epidermis
European Conference on Mathematical and Theoretical Biology, Göteborg, Sweden (Jun 2014)
Towards new insights from a computational model for polarity of root hair cells
ShapeSystems Project Meeting, Umeå, Sweden (Mar 2014)
Modelling planar cell polarity in the Arabidopsis root epidermis
CMMB Conference on Multiscale Modelling in Medicine and Biology, Nottingham, UK (Sep 2012)
The influence of cell-to-cell variability on spatial pattern formation
Workshop on Systems Biology & 2nd Baltic Autumn School, Lübeck, Germany (Sep 2011)
Characterization of trichome patterns on leaves
Conference on Regulation of Plant Growth, Potsdam, Germany (Apr 2010)
New insights into trichome patterning
CND Summer School on Systems Biology Dynamics: From Genes to Organisms, Montreal, Canada (May 2008)
Radiation treatment of cancer
4th Annual Mathematical Biology Summer Workshop, Edmonton, Canada (May 2005)