Pawel Krupinski, Vijay Chickarmane and Carsten Peterson
Computational multiscale modelling of embryo development
Current Opinion in Genetics & Development 22, 613-618 (2012)

Recent advances in live imaging and genetics of mammalian development which integrate observations of biochemical activity, cell-cell signalling and mechanical interactions between cells, pave the way for predictive mathematical multi-scale modelling. In early mammalian embryo development, two of the most critical events which lead to tissue patterning involve changes in gene expression as well as mechanical interactions between cells. We discuss the relevance of mathematical modelling of multi-cellular systems and in particular in simulating these patterns and describe some of the technical challenges one encounters. Many of these issues are not unique for the embryonic system but are shared by other multi-cellular modelling areas.

LU TP 12-29